Title : Anxiety-induced hyperalgesia in female rats is mediated by cholecystokinin 2 receptor in rostral ventromedial medulla and spinal 5-hydroxytryptamine 2B receptor.

Pub. Date : 2019

PMID : 31308730






1 Functional Relationships(s)
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1 RVM microinjection of the CCK2 receptor agonist CCK-8 and intrathecal injection of the 5-HT2B receptor agonist BW723C86 both produced hyperalgesia in female rats after plantar incision, whereas the CCK2 receptor antagonist YM022, the 5-HT2B receptor antagonist RS127445, and the PKCgamma inhibitor C37H65N9O13 decreased the rats" sensitivity to the same stimulus. Sincalide cholecystokinin B receptor Rattus norvegicus