Title : Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1.

Pub. Date : 2019

PMID : 31308624






1 Functional Relationships(s)
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1 Results: Our results showed that DEX dose-dependently restored impaired proliferation of PC12 cells induced by lidocaine,as reflected by the increased cell viability and EdU positive cells, which were consistent with the decreased expression of tumor suppressor protein p21 and increased expression of cell cycle-related cyclin D1 and CDK1. Dexmedetomidine cyclin-dependent kinase 1 Rattus norvegicus