Pub. Date : 2019 Dec
PMID : 31302720
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RATIONALE: The alpha7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | However, the effect of pharmacological agents that have been shown to alter the channel properties of the alpha7 nAChR is not well understood in nicotine reward. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | OBJECTIVES: This study aimed to investigate the impact of alpha7 nAChR pharmacological modulation on nicotine conditioned place preference (CPP) in mice by using positive allosteric modulators (PAMs) and a silent agonist. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | RESULTS: The alpha7 full orthosteric agonist PNU282987 and the Type II alpha7 nAChR PAM PNU120596 reduced nicotine CPP, while the silent agonist NS6740 and Type I PAM NS1738 had no effect. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 5 | CONCLUSIONS: Taken together, our results suggest that modulation of the alpha7 nAChR can play important roles in nicotine CPP in mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 6 | In addition, the Type II alpha7 nAChR PAM PNU120596 attenuated nicotine reward suggesting that endogenous acetylcholine/choline tone is sufficient to reduce nicotine CPP. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 7 | In addition, the Type II alpha7 nAChR PAM PNU120596 attenuated nicotine reward suggesting that endogenous acetylcholine/choline tone is sufficient to reduce nicotine CPP. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |