Title : Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/β-catenin signalling and epithelial-mesenchymal transition (EMT).

Pub. Date : 2019 Oct

PMID : 31302315






5 Functional Relationships(s)
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1 Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT). jatrorrhizine TRAF2 and NCK interacting kinase Homo sapiens
2 Molecular docking revealed that jatrorrhizine, a protoberberine alkaloid, exhibits good binding affinity and interaction with TNIK. jatrorrhizine TRAF2 and NCK interacting kinase Homo sapiens
3 However, the underlying mechanisms of jatrorrhizine targeting TNIK inhibits the proliferation and metastasis of breast cancer cells remain unclear. jatrorrhizine TRAF2 and NCK interacting kinase Homo sapiens
4 RESULTS: The results showed that targeted knockout of TNIK that attenuated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT) expression, the effects were potentiated by the addition of jatrorrhizine. jatrorrhizine TRAF2 and NCK interacting kinase Homo sapiens
5 CONCLUSION: These findings provide an overall perspective that jatrorrhizine potentially restrains TNIK regulating Wnt/beta-catenin signalling and EMT expression for mammary cancer targeted therapy. jatrorrhizine TRAF2 and NCK interacting kinase Homo sapiens