PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31302315-0	2019	Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT).	jatrorrhizine	0-13	TRAF2 and NCK interacting kinase	Homo sapiens	60-64	
31302315-2	2019	Molecular docking revealed that jatrorrhizine, a protoberberine alkaloid, exhibits good binding affinity and interaction with TNIK.	jatrorrhizine	32-45	TRAF2 and NCK interacting kinase	Homo sapiens	126-130	
31302315-3	2019	However, the underlying mechanisms of jatrorrhizine targeting TNIK inhibits the proliferation and metastasis of breast cancer cells remain unclear.	jatrorrhizine	38-51	TRAF2 and NCK interacting kinase	Homo sapiens	62-66	
31302315-7	2019	RESULTS: The results showed that targeted knockout of TNIK that attenuated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT) expression, the effects were potentiated by the addition of jatrorrhizine.	jatrorrhizine	207-220	TRAF2 and NCK interacting kinase	Homo sapiens	54-58	
31302315-10	2019	CONCLUSION: These findings provide an overall perspective that jatrorrhizine potentially restrains TNIK regulating Wnt/beta-catenin signalling and EMT expression for mammary cancer targeted therapy.	jatrorrhizine	63-76	TRAF2 and NCK interacting kinase	Homo sapiens	99-103