Title : WITHDRAWN: Cinobufagin induced cell apoptosis and protective autophagy through the ROS/MAPK signaling pathway.

Pub. Date : 2019 Jul 11

PMID : 31301417






2 Functional Relationships(s)
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1 In addition, treatment with cinobufagin could dramatically increase the expression of ROS and then activate the phosphorylation of MAPK family proteins, including ERK 1/2, JNK and p38. cinobufagin mitogen-activated protein kinase 1 Homo sapiens
2 What"s more, the reaction of apoptosis and autophagy induced by cinobufagin treatment could be reversed by p38 inhibitor SB203580 and JNK inhibitor SP600125 as well as ROS exclusive inhibitor antioxidant N-acetyl cysteine (NAC). cinobufagin mitogen-activated protein kinase 1 Homo sapiens