Title : Vandetanib sensitizes head and neck squamous cell carcinoma to photodynamic therapy through modulation of EGFR-dependent DNA repair and the tumour microenvironment.

Pub. Date : 2019 Sep

PMID : 31299389






3 Functional Relationships(s)
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1 Vandetanib sensitizes head and neck squamous cell carcinoma to photodynamic therapy through modulation of EGFR-dependent DNA repair and the tumour microenvironment. vandetanib epidermal growth factor receptor Homo sapiens
2 PURPOSE: We investigated vandetanib, which selectively blocks EGFR and vascular endothelial growth factor receptor-2 (VEGFR-2), to enhance the efficacy of PDT. vandetanib epidermal growth factor receptor Homo sapiens
3 Next, combined vandetanib and PDT resulted in significant tumour growth delay in vivo that is linked to reduction of PDT-induced EGFR phosphorylation and cellular proliferation, along with loss of tumour vasculature. vandetanib epidermal growth factor receptor Homo sapiens