Title : Gut microbe-derived metabolite trimethylamine N-oxide accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis.

Pub. Date : 2019 Sep

PMID : 31299216






2 Functional Relationships(s)
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1 Furthermore, TMAO increased TGF-beta receptor I expression, which promoted the phosphorylation of Smad2 and up-regulated the expression of alpha-SMA and collagen I. trimethyloxamine SMAD family member 2 Mus musculus
2 CONCLUSIONS: Cardiac function and cardiac fibrosis were significantly exacerbated in mice fed diets supplemented with either choline or TMAO, probably through accelerating the transformation of fibroblasts into myofibroblasts, indicating activation of TGF-betaRI/Smad2 pathway. trimethyloxamine SMAD family member 2 Mus musculus