| Protein Name | SMAD family member 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17126 |
| Gene Symbol | Smad2 |
| UniProt | Q62432 (SMAD2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
299
Total Number of Articles : 379 |
Description |
SMAD family member 2 |
| Gene Summary |
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and tau protein binding activity. Involved in several processes, including heart development; odontoblast differentiation; and positive regulation of epithelial to mesenchymal transition. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; embryonic morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2). [provided by Alliance of Genome Resources, Jul 2025] |
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