Pub. Date : 2019 Sep
PMID : 31295526
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | This study aimed to determine whether resveratrol (Res) delays the progression of 6-hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | This study aimed to determine whether resveratrol (Res) delays the progression of 6-hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | Compared with those in the model group, the number of dopaminergic neurons cells and the expression of PI3K-110alpha, p-Akt Ser473, and pro-caspase-3 in the Res 30 mg/kg group were significantly increased, and the Bax/Bcl-2 ratio and the level of activated caspase-3 was decreased. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 5 | The results indicate that Res ameliorates 6-OHDA-induced apoptosis and motor dysfunction via activating the PI3K/Akt signaling pathway, delaying the progression of Parkinson"s disease (PD) symptoms in this model. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |