Title : A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites.

Pub. Date : 2019 Sep 19

PMID : 31291457






2 Functional Relationships(s)
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Protein Name
Organism
1 At DNA damage sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1029 and 1033, stimulating its ATPase activity to remodel chromatin and promote HR. Lysine sirtuin 1 Homo sapiens
2 At DNA damage sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1029 and 1033, stimulating its ATPase activity to remodel chromatin and promote HR. Lysine sirtuin 1 Homo sapiens