Title : Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25-Foxp3+ T cells.

Pub. Date : 2019 Jul 9

PMID : 31288845






2 Functional Relationships(s)
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1 METHODS: Using BALB/c, FoxP3eGFP and Rag-/- mice, we performed FACS analysis to determine if SM16 blocked de novo TGF-beta-induced Treg generation in vitro and in vivo. treg transforming growth factor alpha Mus musculus
2 CONCLUSIONS: These findings suggest that blockade of TGF-beta signaling is a potentially useful strategy for blunting Treg function to enhance the anti-tumor response. treg transforming growth factor alpha Mus musculus