Title : RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src to facilitate epithelial-mesenchymal transition in lung adenocarcinoma.

Pub. Date : 2019 Jul 8

PMID : 31286874

1 Functional Relationships(s)
Compound Name
Protein Name
1 Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells. Tyrosine catenin beta 1 Homo sapiens