Title : Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling.

Pub. Date : 2019

PMID : 31285948






6 Functional Relationships(s)
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1 Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling. Dinoprostone prostaglandin E synthase Homo sapiens
2 In this study, we aimed to investigate the roles of the PTGES/PGE2 pathway in lung cancer progression. Dinoprostone prostaglandin E synthase Homo sapiens
3 We found that prostaglandin E synthase (PTGES), a key enzyme for PGE2 synthesis in the arachidonic acid pathway, was highly dysregulated in NSCLC. Dinoprostone prostaglandin E synthase Homo sapiens
4 We found that prostaglandin E synthase (PTGES), a key enzyme for PGE2 synthesis in the arachidonic acid pathway, was highly dysregulated in NSCLC. Dinoprostone prostaglandin E synthase Homo sapiens
5 Knockdown of PTGES in lung cancer cells resulted in suppressed cell migration, which was reversed by exogenous PGE2. Dinoprostone prostaglandin E synthase Homo sapiens
6 Taken together, our results show that the upregulated USP9X-PTGES-PGE2 axis contributes significantly to the metastatic features of NSCLC. Dinoprostone prostaglandin E synthase Homo sapiens