Pub. Date : 2019
PMID : 31285948
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 2 | In this study, we aimed to investigate the roles of the PTGES/PGE2 pathway in lung cancer progression. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 3 | We found that prostaglandin E synthase (PTGES), a key enzyme for PGE2 synthesis in the arachidonic acid pathway, was highly dysregulated in NSCLC. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 4 | We found that prostaglandin E synthase (PTGES), a key enzyme for PGE2 synthesis in the arachidonic acid pathway, was highly dysregulated in NSCLC. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 5 | Knockdown of PTGES in lung cancer cells resulted in suppressed cell migration, which was reversed by exogenous PGE2. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 6 | Taken together, our results show that the upregulated USP9X-PTGES-PGE2 axis contributes significantly to the metastatic features of NSCLC. | Dinoprostone | prostaglandin E synthase | Homo sapiens |