Protein Name prostaglandin E synthase
Organism Homo sapiens
Gene ID 9536
Gene Symbol

PTGES

UniProt O14684 (PTGES_HUMAN)
Relationships Total Number of functionally related compound(s) : 148
Total Number of Articles : 239
Description

prostaglandin E synthase

Gene Summary

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

synonyms
  • prostaglandin E synthase
  • MGST1-like 1
  • glutathione S-transferase 1-like 1
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Properties