Title : Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca2+ Release and Cyclic AMP.

Pub. Date : 2019 Sep

PMID : 31285280






1 Functional Relationships(s)
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1 These data reveal a previously unrecognized lysosomal P2RX4- and ADCY1-dependent signaling cascade as a pathway essential for CAD-induced lysosome-dependent cell death and encourage further investigations to find the most potent combinations of CADs and cAMP-inducing drugs for cancer therapy. CyADIC regimen purinergic receptor P2X 4 Homo sapiens