Title : Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway.

Pub. Date : 2019 Oct

PMID : 31281953






1 Functional Relationships(s)
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1 Furthermore, celastrol upregulated death receptor 5 (DR5) at the mRNA and protein levels, and siRNA-mediated DR5 knockdown reduced the killing effect of the combination drug treatment on glioma cells and reduced the activation of caspase-3, caspase-8 and PARP. celastrol poly(ADP-ribose) polymerase 1 Homo sapiens