Title : Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis.

Pub. Date : 2019 Sep 5

PMID : 31278964






2 Functional Relationships(s)
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1 We found that GANT-61 and indomethacin synergistically attenuate cartilage damage and serum levels of inflammatory cytokines TNF-alpha, IL-2 and IL-6 in OA mice. Indomethacin interleukin 2 Mus musculus
2 Moreover, in vitro treatment of GANT-61 and indomethacin synergistically reduced the mRNA expression of TNF-alpha, IL-2 and IL-6 in lipopolysaccharide (LPS)-stimulated C28/I2 chondrocytes. Indomethacin interleukin 2 Mus musculus