Pub. Date : 2019 Jan-Dec
PMID : 31266378
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling. | Curcumin | high mobility group box 1 | Homo sapiens |
| 2 | However, the molecular mechanisms by which curcumin regulates HMGB1-mediated lymphangiogenesis in gastric cancer remain unclear. | Curcumin | high mobility group box 1 | Homo sapiens |
| 3 | The effects of curcumin on HMGB1 and VEGF-D expression were examined by reverse transcription polymerase chain reaction (RT-PCR) and western blot analysis. | Curcumin | high mobility group box 1 | Homo sapiens |
| 4 | The mRNA and protein expression levels of HMGB1 and VEGF-D were significantly eliminated by curcumin administration. | Curcumin | high mobility group box 1 | Homo sapiens |
| 5 | Pre-treatment with the recombinant HMGB1 (rHMGB1) markedly abolished curcumin-reduced VEGF-D expression. | Curcumin | high mobility group box 1 | Homo sapiens |
| 6 | Our findings suggested that curcumin might exert anti-lymphangiogenesis in gastric cancer by inhibition of HMGB1/VEGF-D signaling. | Curcumin | high mobility group box 1 | Homo sapiens |