Title : Clock-Bmal1 mediates MMP9 induction in acrolein-promoted atherosclerosis associated with gut microbiota regulation.

Pub. Date : 2019 Sep

PMID : 31265956






2 Functional Relationships(s)
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1 Interestingly, acrolein exposure contributed to the increased MMP9, decreased Clock and Bmal1, and activated MAPK pathways in human umbilical vein endothelial cells (HUVECs). Acrolein matrix metallopeptidase 9 Homo sapiens
2 Therefore, our findings indicated that acrolein increased the expression of MMP9 through MAPK regulating circadian clock, which was associated with gut microbiota regulation in atherosclerosis. Acrolein matrix metallopeptidase 9 Homo sapiens