Title : Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation.

Pub. Date : 2019

PMID : 31263710






1 Functional Relationships(s)
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1 Results: Relative to control, montelukast significantly suppressed gene expressions of MMP-2, MMP-9, and IL-1beta, induced gene expressions of arginase-1 and IL-10, enhanced the expression of the arginase-1 cell surface protein, and increased the protein concentration of IL-10. montelukast arginase, liver Mus musculus