Pub. Date : 2019 Jun
PMID : 31257059
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/beta-catenin axis. | Quercetin | catenin beta 1 | Homo sapiens |
| 2 | Moreover, the anti-tumor effect of quercetin is correlated with WNT/beta-catenin pathway and miRNA dysregulation. | Quercetin | catenin beta 1 | Homo sapiens |
| 3 | In the present study, we aimed to further investigate whether quercetin can exert its anti-tumor function by regulating miR-22 together with miR-22 downstream pathway WNT1/beta-catenin in OSCC. | Quercetin | catenin beta 1 | Homo sapiens |
| 4 | RT-qPCR assay showed that quercetin promoted miR-22 expression and suppressed WNT1 and beta-catenin expression in OSCC cells, whereas this effect was abrogated by miR-22 inhibitor. | Quercetin | catenin beta 1 | Homo sapiens |
| 5 | Quercetin inhibited the growth of OSCC xenograft tumors by inducing miR-22 expression and repressing WNT1/beta-catenin pathway in vivo. | Quercetin | catenin beta 1 | Homo sapiens |
| 6 | Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC. | Quercetin | catenin beta 1 | Homo sapiens |
| 7 | Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC. | Quercetin | catenin beta 1 | Homo sapiens |