Pub. Date : 2019 Oct
PMID : 31255721
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation. | Cyclic AMP | Yes1 associated transcriptional regulator | Homo sapiens |
| 2 | Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation. | Cyclic AMP | Yes1 associated transcriptional regulator | Homo sapiens |
| 3 | Taken together, these data demonstrate that cAMP downregulates EPAC1 gene expression via disrupting the actin cytoskeleton, which inhibits YAP/TAZ-TEAD activity in concert with HDAC-mediated histone deacetylation at the EPAC1 proximal promoter. | Cyclic AMP | Yes1 associated transcriptional regulator | Homo sapiens |