Title : Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice.

Pub. Date : 2019 Sep 1

PMID : 31251998






1 Functional Relationships(s)
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1 Moreover gliotic specific inflammatory markers like glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor protein-1 (Iba-1), iNOS and COX-2 were found to be expressed more in MPTP intoxicated mice, Further the levels of proinflammatory cytokines like IL-beta, IL-6, and TNF-alpha were significantly upregulated in MPTP intoxicated mice, these deleterious responses were diminished to extend neuroprotection by PHL treatment. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine interleukin 6 Mus musculus