Title : Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.

Pub. Date : 2019 Oct

PMID : 31246318






2 Functional Relationships(s)
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1 In in vitro experiments, PDX treatment increased AMP-activated protein kinase (AMPK) phosphorylation and SIRT1 expression and attenuated palmitate-induced fetuin-A and SeP expression and insulin resistance in hepatocytes. Palmitates insulin Homo sapiens
2 AMPK or SIRT1 siRNA mitigated the suppressive effects of PDX on palmitate-induced fetuin-A through NF-kappaB and SeP expression linked to FOXO1 and insulin resistance. Palmitates insulin Homo sapiens