Title : Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.

Pub. Date : 2019 Jun 20

PMID : 31226791






1 Functional Relationships(s)
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Protein Name
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1 The resultant analog sequence Ac-Leu-Thr-Phe-Aib-Glu-Tyr-Trp-Gln-Leu-Cba-Aib-Ser-Ala-Ala-NH2 exhibited high-affinity target binding (Mdm2 Kd = 43 nM) and significant alpha-helicity in circular dichroism studies. Tyrosine MDM2 proto-oncogene Homo sapiens