Title : Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

Pub. Date : 2019 Jun 21

PMID : 31225620






1 Functional Relationships(s)
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1 To elucidate the mechanism of AHR-mediated repression of lipid synthesis, we demonstrated that selective AHR modulators, SGA360 and SGA315 increased the protein turnover of the mature sterol regulatory element-binding protein (mSREBP-1), the principal transcriptional regulator of the fatty acid synthesis pathway. Fatty Acids CCHC-type zinc finger nucleic acid binding protein Homo sapiens