Title : mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation.

Pub. Date : 2017 Sep 20

PMID : 31225434






1 Functional Relationships(s)
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1 The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced by mutant IDH1/2 (mIDH1/2), has been suggested to promote epigenetic deregulation during tumorigenesis. tetramethylenedisulfotetramine isocitrate dehydrogenase 1 (NADP+), soluble Mus musculus