Protein Name isocitrate dehydrogenase 1 (NADP+), soluble
Organism Mus musculus
Gene ID 15926
Gene Symbol

Idh1

UniProt O88844 (IDHC_MOUSE)
Relationships Total Number of functionally related compound(s) : 101
Total Number of Articles : 109
Description

isocitrate dehydrogenase 1 (NADP+), soluble

Gene Summary

Enables isocitrate dehydrogenase (NADP+) activity. Involved in NADPH regeneration. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in mitochondrion. Is active in cytosol and peroxisomal matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • isocitrate dehydrogenase [NADP] cytoplasmic
  • IDH
  • IDP
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Properties