Title : Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.

Pub. Date : 2019 Aug 20

PMID : 31217077






2 Functional Relationships(s)
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1 The expression of a 5-oxoproline-catalyzing enzyme, gamma-glutamylcyclotransferase (GGCT), was also upregulated by IGF-1 treatment and further enhanced by the addition of EP2/EP4 inhibitors. Pyrrolidonecarboxylic Acid gamma-glutamylcyclotransferase Homo sapiens
2 The expression of a 5-oxoproline-catalyzing enzyme, gamma-glutamylcyclotransferase (GGCT), was also upregulated by IGF-1 treatment and further enhanced by the addition of EP2/EP4 inhibitors. Pyrrolidonecarboxylic Acid gamma-glutamylcyclotransferase Homo sapiens