Title : miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.

Pub. Date : 2019 Jun 13

PMID : 31195981






2 Functional Relationships(s)
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1 RESULTS: NAFLD hepatic tissues and FFA-treated HepG2 and Huh-7 cells presented excess lipid production and TG secretion, accompanied by miR-122 upregulation, Sirt1 downregulation, and potentiated lipogenesis-related genes. Fatty Acids, Nonesterified sirtuin 1 Homo sapiens
2 Knockdown of miR-122 effectively mitigated excessive lipid production and suppressed the expression of lipogenic genes in FFA-treated HepG2 and Huh-7 cells via upregulating Sirt1. Fatty Acids, Nonesterified sirtuin 1 Homo sapiens