Pub. Date : 2019 Jun 12
PMID : 31189969
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transient overexpression of miR-25 inhibited TGF-beta and its type 1 receptor (TGFBR1) mRNA expression, TGF-beta-induced Smad2 phosphorylation and subsequent collagen1alpha1 induction in LX-2 cells. | mir-25 | transforming growth factor alpha | Homo sapiens |
| 2 | Transient overexpression of miR-25 inhibited TGF-beta and its type 1 receptor (TGFBR1) mRNA expression, TGF-beta-induced Smad2 phosphorylation and subsequent collagen1alpha1 induction in LX-2 cells. | mir-25 | transforming growth factor alpha | Homo sapiens |
| 3 | We propose that miR-25 acts as a negative feedback anti-fibrotic control during HSC activation by reducing the reactivity of HSCs to TGF-beta-induced collagen expression and modulating the cross-talk between Notch, Wnt and TGF-beta signaling. | mir-25 | transforming growth factor alpha | Homo sapiens |
| 4 | We propose that miR-25 acts as a negative feedback anti-fibrotic control during HSC activation by reducing the reactivity of HSCs to TGF-beta-induced collagen expression and modulating the cross-talk between Notch, Wnt and TGF-beta signaling. | mir-25 | transforming growth factor alpha | Homo sapiens |