Title : Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction.

Pub. Date : 2019 Sep

PMID : 31163256






1 Functional Relationships(s)
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1 Inhibition of CDK5 with myricetin or roscovitine, a CDK5 inhibitor attenuates thapsigargin induced p66Shc serine 36 phosphorylation and also reduced mitochondrial dysfunction by decreasing mitochondrial ROS and caspase-3 activation. ros cyclin dependent kinase 5 Homo sapiens