Title : Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.

Pub. Date : 2019 Jul 23

PMID : 31154815






1 Functional Relationships(s)
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1 To translate these findings into a clinical setting, we show that AnxA1 plasma levels are reduced in human and murine stroke and that AnxA1 is able to act on human platelets, suppressing classic thrombin-induced inside-out signaling events (eg, Akt activation, intracellular calcium release, and Ras-associated protein 1 [Rap1] expression) to decrease alphaIIbbeta3 activation without altering its surface expression. Calcium coagulation factor II, thrombin Homo sapiens