Pub. Date : 2019 Jul 15
PMID : 31152077
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects of nicotine were abolished by the selective alpha7 nicotinic acetylcholine receptor (nAChR) blocker, methyllycaconitine . | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |