Title : Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS).

Pub. Date : 2019 May 30

PMID : 31152038






1 Functional Relationships(s)
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1 We will perform a randomised clinical trial (RCT) with colchicine, which enhances the expression of HSPB8 and of several autophagy players, blocking TDP-43 accumulation and exerting crucial activities for MNs function. Colchicine heat shock protein family B (small) member 8 Homo sapiens