CPRiL

Protein Name	heat shock protein family B (small) member 8
Organism	Homo sapiens
Gene ID	26353
Gene Symbol	HSPB8
UniProt	Q9UJY1 (HSPB8_HUMAN)
Relationships	Total Number of functionally related compound(s) : 61 Total Number of Articles : 53
Description	heat shock protein family B (small) member 8
Gene Summary	The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
synonyms	heat shock protein beta-8 E2-induced gene 1 protein alpha-crystallin C chain heat shock 22kDa protein 8 heat shock 27kDa protein 8 heat shock protein family B member 8 protein kinase H11 small stress protein-like protein HSP22 CMT2L DHMN2 E2IG1 H11 HMN2 HMN2A HMND2 HSP22 HSPB8-N1 HSPB8-N2 Click to show/hide the synonyms
Properties