Title : Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS).

Pub. Date : 2019 May 30

PMID : 31152038






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The heat shock protein B8 (HSPB8) recognises and promotes the autophagy-mediated removal of misfolded mutant SOD1 and TDP-43 fragments from ALS motor neurons (MNs), as well as aggregating species of dipeptides produced in C9ORF72-related diseases. Dipeptides heat shock protein family B (small) member 8 Homo sapiens
2 The heat shock protein B8 (HSPB8) recognises and promotes the autophagy-mediated removal of misfolded mutant SOD1 and TDP-43 fragments from ALS motor neurons (MNs), as well as aggregating species of dipeptides produced in C9ORF72-related diseases. Dipeptides heat shock protein family B (small) member 8 Homo sapiens