Title : Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-β1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene.

Pub. Date : 2019 May

PMID : 31151763






4 Functional Relationships(s)
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1 Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-beta1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene. ursolic acid mechanistic target of rapamycin kinase Homo sapiens
2 Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum. ursolic acid mechanistic target of rapamycin kinase Homo sapiens
3 Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum. ursolic acid mechanistic target of rapamycin kinase Homo sapiens
4 Ursolic acid from Bushen Yijing Formula inhibits human umbilical vein endothelial cell EndMT and fibrosis, mediated by AKT/mTOR signaling and Snail gene expression. ursolic acid mechanistic target of rapamycin kinase Homo sapiens