Pub. Date : 2019
PMID : 31139627
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanical Stretch Induces mTOR Recruitment and Activation at the Phosphatidic Acid-Enriched Macropinosome in Muscle Cell. | Phosphatidic Acids | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Mechanical load has been well-appreciated to induce mTOR activation that leads to skeletal muscle growth through phospholipase D (PLD) activity and phosphatidic acid (PA) production. | Phosphatidic Acids | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Mechanical load has been well-appreciated to induce mTOR activation that leads to skeletal muscle growth through phospholipase D (PLD) activity and phosphatidic acid (PA) production. | Phosphatidic Acids | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | While PA produced by PLD1 is critical for mTOR activation upon mitogenic stimulation at the lysosome, it is unclear where PA is produced upon mechanical stimulation in skeletal muscle. | Phosphatidic Acids | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | Furthermore, mTOR is recruited to the PA-enriched macropinosome, and its downstream signaling is activated. | Phosphatidic Acids | mechanistic target of rapamycin kinase | Homo sapiens |
| 6 | Our findings reveal the underpinning of mechanical activation of mTOR signaling, and more importantly, the stretch-induced PA-macropinosome as a new platform for mTOR activation. | Phosphatidic Acids | mechanistic target of rapamycin kinase | Homo sapiens |