Title : Hyperglycemia induces NF-κB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin.

Pub. Date : 2019 Aug

PMID : 31136032






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1 Hyperglycemia induces NF-kappaB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin. Metformin glucagon-like peptide 1 receptor Rattus norvegicus
2 We further proved that metformin restored high glucose-inhibited GLP-1R mRNA expression and decreased high glucose evoked inflammation in HBZY-1 cells. Metformin glucagon-like peptide 1 receptor Rattus norvegicus
3 On the basis of these findings, we conclude that high glucose lowers GLP-1R expression and leads to inflammatory responses in mesangial cells, which can be reversed by metformin. Metformin glucagon-like peptide 1 receptor Rattus norvegicus
4 These data support the rationale of combinative therapy of metformin with GLP-1R agonists in DN. Metformin glucagon-like peptide 1 receptor Rattus norvegicus