Title : Isoflavone biochanin A, a novel nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element activator, protects against oxidative damage in HepG2 cells.

Pub. Date : 2019 Jul

PMID : 31131946






5 Functional Relationships(s)
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1 Isoflavone biochanin A, a novel nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element activator, protects against oxidative damage in HepG2 cells. Isoflavones NFE2 like bZIP transcription factor 2 Homo sapiens
2 Isoflavone biochanin A, a novel nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element activator, protects against oxidative damage in HepG2 cells. Isoflavones NFE2 like bZIP transcription factor 2 Homo sapiens
3 In this study, the effects of isoflavones on the nuclear factor E2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway and the underlying molecular mechanisms were investigated. Isoflavones NFE2 like bZIP transcription factor 2 Homo sapiens
4 Results showed that isoflavones are potential Nrf2-ARE activators while their activities were structure dependent. Isoflavones NFE2 like bZIP transcription factor 2 Homo sapiens
5 These findings indicate that the protective actions of dietary isoflavones against oxidative damage may be at least partly due to their ability to enhance the intracellular antioxidant response system by modulating the Nrf2-ARE signaling pathway. Isoflavones NFE2 like bZIP transcription factor 2 Homo sapiens