Title : Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity.

Pub. Date : 2019

PMID : 31131306






3 Functional Relationships(s)
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1 Recently we found that cancers of the liver and multiple other tissues suppress the catabolism of BCAAs, thereby facilitating the chronic activation of mTORC1. Amino Acids, Branched-Chain CREB regulated transcription coactivator 1 Mus musculus
2 Our results unveil how mTORC1"s nutrient-sensing arm can be manipulated by tumors, and suggest that restoring BCAA catabolism may help control mTORC1 activity in cancer cells. Amino Acids, Branched-Chain CREB regulated transcription coactivator 1 Mus musculus
3 Our results unveil how mTORC1"s nutrient-sensing arm can be manipulated by tumors, and suggest that restoring BCAA catabolism may help control mTORC1 activity in cancer cells. Amino Acids, Branched-Chain CREB regulated transcription coactivator 1 Mus musculus