Title : Stabilization of Brain Mast Cells Alleviates LPS-Induced Neuroinflammation by Inhibiting Microglia Activation.

Pub. Date : 2019

PMID : 31130850






2 Functional Relationships(s)
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1 Results: In this study, intraperitoneal injection of 1 mg/kg LPS induced mast cell activation in hypothalamus and cognitive dysfunction in rats, and that this process can be repressed by the mast cell stabilizer cromolyn (200 mug). Cromolyn Sodium toll-like receptor 4 Mus musculus
2 We also found that LPS selectively provokes upregulation of H1R, H4R, PAR2, and TLR4, but downregulation of H2R and H3R, in ipsilateral hypothalamus microglia; these effects were partially inhibited by cromolyn. Cromolyn Sodium toll-like receptor 4 Mus musculus