Pub. Date : 2019 May 31
PMID : 31128467
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 2 | CZ-48 activated SARM1 via a conformational change of the auto-inhibitory domain and dimerization of its catalytic domain. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 3 | CZ-48 acted selectively, activating SARM1 but inhibiting CD38. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 4 | CZ-48 is a specific modulator of SARM1 functions in cells. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |