Pub. Date : 2019 Mar-Apr
PMID : 31128031
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A study on the mechanism of rapamycin mediating the sensitivity of pancreatic cancer cells to cisplatin through PI3K/AKT/mTOR signaling pathway. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | PURPOSE: To study the mechanism of rapamycin mediating the sensitivity of pancreatic cancer cells to cisplatin through phosphatidylinositol 3-kinase (PI3K)/serine-threonine kinase (AKT)/mammalian target of rapamycin (mTOR) signaling pathway in vitro. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | PURPOSE: To study the mechanism of rapamycin mediating the sensitivity of pancreatic cancer cells to cisplatin through phosphatidylinositol 3-kinase (PI3K)/serine-threonine kinase (AKT)/mammalian target of rapamycin (mTOR) signaling pathway in vitro. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | 3: Rapamycin combined with cisplatin could inhibit the expressions of PI3K, AKT and phosphorylated mTOR (p-mTOR) in pancreatic cancer cells (p<0.05). | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | 3: Rapamycin combined with cisplatin could inhibit the expressions of PI3K, AKT and phosphorylated mTOR (p-mTOR) in pancreatic cancer cells (p<0.05). | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 6 | CONCLUSION: Rapamycin combined with cisplatin can alter the PI3K/AKT/mTOR signal transduction pathway which leads to markedly increased cell apoptosis rate, indicating that rapamycin can mediate the sensitivity of pancreatic cancer cells to cisplatin. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 7 | CONCLUSION: Rapamycin combined with cisplatin can alter the PI3K/AKT/mTOR signal transduction pathway which leads to markedly increased cell apoptosis rate, indicating that rapamycin can mediate the sensitivity of pancreatic cancer cells to cisplatin. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |