Title : Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.

Pub. Date : 2019 Jul

PMID : 31127856






2 Functional Relationships(s)
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1 Here, we show that the antifolates lometrexol and pemetrexed are inhibitors of SHMT2 and solve the first SHMT2-antifolate structures. lometrexol serine hydroxymethyltransferase 2 Homo sapiens
2 Here, we show that the antifolates lometrexol and pemetrexed are inhibitors of SHMT2 and solve the first SHMT2-antifolate structures. lometrexol serine hydroxymethyltransferase 2 Homo sapiens