Title : Cilostazol add-on therapy for celecoxib synergistically inhibits proinflammatory cytokines by activating IL-10 and SOCS3 in the synovial fibroblasts of patients with rheumatoid arthritis.

Pub. Date : 2019 Dec

PMID : 31123968






3 Functional Relationships(s)
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1 Cilostazol add-on therapy for celecoxib synergistically inhibits proinflammatory cytokines by activating IL-10 and SOCS3 in the synovial fibroblasts of patients with rheumatoid arthritis. Celecoxib suppressor of cytokine signaling 3 Homo sapiens
2 Cilostazol and celecoxib cotreatment similarly showed synergistic increase in SOCS3 mRNA levels. Celecoxib suppressor of cytokine signaling 3 Homo sapiens
3 Summarizing, cotreatment with cilostazol and celecoxib exhibited a synergistic increase in IL-10 production and SOCS3 expressions, thereby resulted in synergistic decreases in IL-1beta mRNA, IL-6 mRNA expression and TNF-alpha synthesis in association with synergistic decreases in COX-2 and PGE2 protein expression in the RA synovial fibroblasts. Celecoxib suppressor of cytokine signaling 3 Homo sapiens