Pub. Date : 2019 May 22
PMID : 31118051
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although Metformin has antiproliferative and proapoptotic effects on breast cancer, the heterogenous nature of this disease affects the response to metformin leading to the activation of pro-invasive signalling pathways that are mediated by the focal adhesion kinase PYK2 in pure HER2 phenotype breast cancer. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | The activation of PYK2 by metformin in pure HER2 phenotype (HER2+/ER-/PR-) cell lines was investigated by microarrays, quantitative real time PCR and immunoblotting. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | The activation of PYK2 by metformin in pure HER2 phenotype (HER2+/ER-/PR-) cell lines was investigated by microarrays, quantitative real time PCR and immunoblotting. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | Cell migration and invasion PYK2-mediated and in response to metformin were determined by wound healing and invasion assays using HER2+/ER-/PR- PYK2 knockdown cell lines. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | The effect of PYK2 and metformin on tumour initiation and invasion of HER2+/ER-/PR- breast cancer stem-like cells was performed using the in vitro stem cell proliferation and invasion assays. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | RESULTS: Our study showed for the first time that pure HER2 breast cancer cells are more resistant to metformin treatment when compared with the other breast cancer phenotypes. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 7 | The role of PYK2 in promoting invasion of metformin resistant HER2 breast cancer cells was confirmed through investigating the effect of PYK2 knockdown and metformin on cell invasion and by proteomic analysis of associated cellular pathways. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 8 | The role of PYK2 in promoting invasion of metformin resistant HER2 breast cancer cells was confirmed through investigating the effect of PYK2 knockdown and metformin on cell invasion and by proteomic analysis of associated cellular pathways. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 9 | CONCLUSIONS: We provide evidence of a PYK2-driven pro-invasive potential of metformin in pure HER2 cancer therapy and propose that metformin-based therapy should consider the molecular heterogeneity of breast cancer to prevent complications associated with cancer chemoresistance, invasion and recurrence in treated patients. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |