Title : The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver.

Pub. Date : 2019 Jul

PMID : 31111189






4 Functional Relationships(s)
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1 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene cytochrome P450 family 4 subfamily F member 3 Homo sapiens
4 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene cytochrome P450 family 4 subfamily F member 3 Homo sapiens